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What is the ArrayXPath?
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Biological pathways can provide key information on the organization of biological systems.
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ArrayXPath (http://www.snubi.org/software/ArrayXPath/) is a web-based service for mapping and visualizing microarray gene-expression data with integrated biological pathway resources using Scalable Vector Graphics (SVG).
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By seriously integrating major bio-databases and searching pathway resources, ArrayXPath automatically maps different types of identifiers from microarray probes and pathway elements. When one inputs gene-expression clusters, ArrayXPath outputs a list of the best matching pathways for each cluster.
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Fisher's exact test is applied to evaluate the statistical significance of the association between a cluster and a pathway. To correct the multiple-comparison problem, ArrayXPath calculates the False Discovery Rate (FDR). ArrayXPath outputs Javascript-enabled SVG for web-enabled interactive visualization of pathways integrated with gene-expression profiles.
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